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KMID : 0377219830080010061
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Medical Journal of Chosun Univercity
1983 Volume.8 No. 1 p.61 ~ p.71
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An Experimental Study on the Myocardial Protection Effect of the Steroid mixed Cardioplegic Solution
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Abstract
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The increasing use of cardioplegic solution for the reduction of ischemic tissue injury requires that all cardioplegic solution be carefully assessed for any protective or damaging properties. This study describes functional assessment of the efficiency of steriod in cardioplegic solution by using a Langendorff´s perfusion model.
Isolated rat hearts were subject to a 2 minute period of coronary infusion with the steriod mixed cold cardioplegic solution inimediately before and also at the midpoint of a 60 minutes period of hypothermic(10±1℃) ischemic arrest.
The result of this study were as follows:
1) Spontaneous heart beat after ischsrnic arrest occured 14 second later Langendorff´s reperfusion in the steriod mixed Young & GIK group and 16 second later in the control group. (Young e GIK without steriod) A good recovery state of spontaneous heart beat was shower in both groups.
2) The percentage of recoveries of heart rate during the 30 minute after postischemic Langendorff´s reperfusion was ; at first 5 minute 106.3±2.7% (p<0.05) in the steriod mixed Young & GIK group.
This percentage of recovery of the steriod mixed Young & GIK group was significantly greater than the control group during the first 5 minute course.
3) The percentage of recovery of coronary flow during the 30 minute after postischemic Langendorff´s reperfusion was ; at first 5 minute 101±8.2% in the steriod mixed Young & GIK group.
This percentage of recovery of the steriod mixed Young & GIK group was not significantly than the control group during the first 5 minute.
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